Rat liver and plasma lipids after carbon tetrachloride administration

Rat Liver and Plasma Lipids after Carbon Tetrachloride Administration.

Oral administration of CC14 to rats produced (a) decreased cholesterol, phospholipid, and triglyceride plasma concentrations and elevated triglyceride levels in liver, (6) several hours later, a growing increase in plasma FFA, and (c) still later, increased plasma cholesterol, triglyceride, and phospholipid concentrations and continually rising liver triglyceride. The accumulation of hepatic tr...

A note on the stability of conjugated diene absorption of rat liver microsomal lipids after carbon tetrachloride poisoning.

Liver microsomal lipid peroxidation has been observed in fatal human CCl(4) poisoning, in rats with fatty livers induced by CCl(4) or by yellow phosphorus, and in mice poisoned with 1,1,2,2-tetrachloroethane. These observations suggest the possibility that other instances of toxic liver injury may involve lipid peroxidation. Cases of acute, fatal, toxic liver injury (e.g., from halothane anesth...

Effect of carbon tetrachloride administration on the synthesis of triglycerides and phospholipids in rat liver.

In vivo incorporation of choline-methyl-(14)C into liver lecithin and its biosynthetic precursors was studied in CCl(4)-treated rats. Radioactivity in cytidine diphosphoryl (CDP-)choline and lecithin was reduced to one-third of control levels, whereas that of phosphorylcholine was increased to 4.7 times control levels. Incorporation of phosphorylcholine-(32)P into lecithin by homogenates prepar...

Lipid Alterations of Liver Microsomal Fraction and Plasma Lipoproteins after Carbon Tetrachloride Poisoning

of 3-methylcholanthrene on liver steatosis and triglyceride secretion, suggesting that the initial steps of CCI4 hepatotoxicity are not associated with the interference by the polycyclic hydrocarbon; 3-methylcholanthrene would act on only those metabolites responsible for hepatic necrosis. To obtain a better understanding of the lack of effect by 3-methylcholanthrene on fatty liver and triglyce...

Alteration of tumor response in rat liver by carbon tetrachloride.